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Herpes simplex virus(HSV)is known to establish latency in human trigeminal ganglia.It has been speculated that the virus might be also present in latent fashion in normal human brain,where it might be responsible for conditions such as herpes simplex encephalitis,and less plausibly as a cause for multiple sclerosis of Alzheimer's disease.To test the possibility that HSV exists in normal human grain,we utilized the polymerase chain reaction to assess the frequency and distribution of HSN genomes in the nervous system tissues of patients dying of nonneurological causes.The study has confirmed the previous demonstration of latent HSV in trigeminal ganglia in normal humans.The frequency of latent HSV in trigeminal ganglia is in general agreement with results obtained by explanation of ganglia.In addition,HSV sequences could be amplified from a variety of other central nervous system structures,suggesting the presence of the virus in latent state in normal central nervous system.Whether the virus is important in the pathogenesis of nervous system diseases of not answered by these studies.However,it appears that the virus,commonly latent in trigeminal ganglia,may be detectable with lesser frequency in normal brain. |
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herpes simplex virus
herpes simplex virus,latency
herpes simplex virus,localization of
polymerase chain reaction
sensory ganglia
trigeminal ganglia
viral infection,CNS
viral isolation
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